Key Responsibilities n Design and oversee DMPK studies, review and summarize results, integrate ADME, PK, and PK/PD information to guide multi-disciplinary team efforts in lead optimization and candidate selection. n Lead BBB penetration strategy across discovery programs, Drive brain exposure- efficacy relationship and investigate efflux transporter liability（P-gp，BCRP）and mitigation strategies n Manage external CROs, review study protocol, study results, and finalize reports to ensure high quality and on-time execution of DMPK studies. n Experience in targeted protein degradation (TPD) and/or AI-driven drug discovery (AIDD) is highly preferred

Qualifications • MSc or PhD in Medicinal Chemistry, Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, or related disciplines. • Over 3 years of relevant experience in the pharmaceutical industry or CROs, with a focus on CNS drug development, BBB penetration optimization, or targeted protein degradation. • Direct hands-on experience and strong trouble shooting skills in most in vitro and in vivo DMPK studies. Solid understanding of ADME principles, PK/PD relationships, and translational DMPK concepts. • Strong analytical, organizational and communication skills